UMRAM-National Magnetic Resonance Research Center, Bilkent University, Turkey.Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna, Austria.Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Turkey.UNAM-National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Turkey.Interdisciplinary Graduate Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Turkey.The zebrafish will be a powerful tool for uncovering the mysteries of the aging brain. Therefore, this animal model can provide information about potential therapies that could be translated directly into human populations or provide a more focused treatment direction for testing in other mammalian animal models. Drug effect and toxicity can be easily tested in the zebrafish. Like humans this model organism ages gradually, displays similar behavioral properties and social characteristics, and in addition, there is a wealth of molecular and genetic tools to uncover the cellular mechanism that contribute to age-related cognitive declines. Recently the zebrafish has emerged as a promising model for understanding the cognitive and neurobiological changes during aging, as well as its use with potential anti-aging interventions. Our current knowledge on types and durations of potential anti-aging therapies is quite limited. As the lifespan increases, there will be a need for maintaining a healthy state for these individuals. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. Across the world, the aging population is expanding due to an increasing average life expectancy.
0 kommentar(er)
